Current Job Openings:
A Postdoctoral Associate Position in Structural Biology: Daniel Capelluto's Lab
The Daniel Capelluto’s laboratory is looking for a Postdoctoral Associate candidate for structural biology, specifically in the design of a peptide to be employed to block platelet-cancer cell interactions. The Capelluto’s lab uses a combination of structural, biophysical, cell-based, and computational tools to establish how protein domains signal through membrane lipids.
Research Project: The successful candidate will contribute to a project, carried out in collaboration with Virginia Tech cell biologists, chemical engineers, and bioinformaticians, to develop peptides that will be able to bind to specific lipids at the platelet and leukemia cell surfaces to block platelet-leukemia cell interactions. We plan to use NMR and other structural approaches to assess the folding and stability of the peptides followed by their encapsulation to nanoparticles for delivery purposes. Nanocarriers will be evaluated using cell-cell adhesion assays and in endothelial cell-coated microfluidic devices.
The research will be conducted in the Capelluto laboratory of the Biocomplexity Institute at Virginia Tech. Our primary technique is solution-state NMR spectroscopy complemented by biophysical techniques, including surface plasmon resonance, circular dichroism, atomic force microscopy, isothermal calorimetry, and dynamic light scattering).
Qualifications: The candidate must hold a Ph.D. in Structural Biology, Biophysics, Biochemistry or related field. Previous experience in NMR spectroscopy is required. Specifically, the candidate should be able to collect, process, and interpret NMR data. Experience in assigning protein NMR resonances is essential. Computational skills, including protein molecular docking is preferred. We offer a one-year contract, subject to renewal. Salary commensurate with experience. Starting date will be July 1, 2018.
Interested candidates should submit a curriculum vitae, and contact of three references upon applying online at: www.jobs.vt.edu (Posting #SR0180001) and to: Daniel G. S. Capelluto, Associate Professor in Biological Sciences and Biocomplexity Institute at Virginia Tech Email: firstname.lastname@example.org
A PhD student position is available in, Alexey Onufriev's computational biophysics lab.
Description: The work will focus on understanding fundamental aspects of DNA compaction in living cells. About 2 meters of the DNA is confined in a cell nucleus, which is only several microns in diameter. The details of the compaction, still poorly understood, affect vital cellular processes such as gene expression and cell differentiation. Essentially, we are creating a new field "Physical Epigenetics": the idea is that the very fundamental processes that affect key elements of Life must be governed by simple principles that a physicist can uncover. Specifically, we use polymer models to simulate time-evolution of chromosomes within the nucleus to understand which factors affect the resulting spatial and temporal fractal patterns, some of which might help understand cellular aging. We will work in close collaboration with an experimental lab. If interested, please contact Alexey Onufriev: email@example.com.